Industry Led Abstracts

• Experiences of a probiotic food supplement: retrospective analysis of e-commerce reviews

  Placebo-controlled trials in healthy people indicated Bifidobacterium longum 1714™ may improve perceived stress and anxiety(2), and change brainwave activity associated with energy/vitality(3). This retrospective analysis of e-commerce reviews explored reasons and experiences of individuals who purchased a food supplement (Zenflore®, produced for PrecisionBiotics Group Ltd, Ireland) containing Bifidobacterium longum 1714 and B vitamins (Probiotic).

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• Development & application of a pipeline for strain level classification of the Infant Microbiome using metagenome data

  Validation of a computational shotgun metagenomics pipeline for quantifying abundance and strain-level classification specifically within the infant microbiome by using a curated infant database.

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• Propionibacterium freudenreichii P.UF1 Reduces Fat Accumulation in Caenorhabditis elegans

  Propionibacteria freudenreichii P.UF1® significantly reduced fat accumulation in C. elegans under non-obesogenic conditions and could be a viable nutrient for sports nutrition, weight management, and body shaping through its beneficial effect on fat metabolism.

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• Modulation of the peripheral innate immune system towards increased phagocytic capabilities following probiotic supplementation with B. subtilis CU1

  The probiotic LifeinUTM Bacillus subtilis CU1 (BSCU1) prepared immune cells for a better response to microbial challenges and enhanced phagocytic activity. This clinical study gives insight into the mechanisms by which BSCU1 support immune defense mechanisms against pathogens.

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• The gut-brain axis Intake of Lactiplantibacillus plantarum​ HEAL9 Improves Cognition in Moderately Stressed Subjects: A Randomized Controlled Study

  Probi® Sensia is a new probiotic concept by Probi® based on clinical and scientific data that supports improved cognition by boosting learning and working memory as well as improved mood and sleep.

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• Metabolic phenotyping of the gut microbiome using dynamic breath analysis

  This study utilizes breath analysis to measure disease-associated metabolites generated by the microbiome in the digestive system. The simplicity of breath collection enables broad applications, facilitating large-scale investigations to understand the impact of these metabolites on diseases across diverse populations.

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• Improvements in sleep and wellbeing outcomes during supplementation with a probiotic supplement containing Bifidobacterium longum 1714 - a prospective experience programme in hybrid workers

  This real-world study of probiotic supplementation in hybrid workers generated findings which support existing clinical evidence in healthy people associating Bifidobacterium longum 1714 with improvements related to sleep, feelings of stress and overall wellbeing.

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• Exploring the Gut-Liver Axis Using Organ-on-Chips and Liver Spheroids: A Path to Improving Liver Health

  The Gut-Liver axis involves microbiota, intestinal barrier, immune system, and circulatory system. Our research introduces a novel multi-compartmental organ-on-chip platform that fluidically connects human reconstructed gut and liver tissues, replicating physiological bloodstream conditions and emerging as a reliable in vitro model.

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• A Randomized, Double-Blind, Placebo-Controlled Clinical Trial: Effect of Streptococcus thermophilus iHA318 on Relieving Dry Eye Syndrome and Eye Discomfort

  Streptococcus thermophilus iHA318 is the first probiotic strain discovered to have functions in relieving Dry Eye Syndrome and eye discomfort. Our double-blind clinical trial has indicated that iHA318 can efficiently induce tear secretion and reduce inflammation.

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• Breast Milk Isolated Lactobacillus helveticus UA881 Alleviates Hyperlipidemia and Hyperuricemia, Generates Micro-Nutrients, and Activates Antioxidant Systems

  Lactobacillus helveticus UA881 is a versatile probiotic strain that can comprehensively improve cardiovascular health and relieve gout by lowering cholesterol, triacylglyceride and uric acid, as well as activating antioxidant systems, generating essential vitamins and inhibiting inflammation.

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• The Probiotic Bacillus velezensis strain BV379 Decreases Abdominal Bloating without Disrupting the Commensal Gut Microbiota: A Randomized, Double-Blind, Placebo-Controlled Trial in Healthy Adults

  Results from BIO-CAT Microbials’ first-in-human study of the probiotic Bacillus velezensis BV379 demonstrate that daily supplementation for 8 weeks is safe and enhanced digestive health by significantly increasing the proportion of participants showing improvement in abdominal bloating, compared to placebo.

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• Preclinical Relevance of Pediococcus acidilactici CECT 9879 (pA1c®) for the Prevention of Diabetes-Related Conditions.

  Different probiotics have emerged as a natural alternative to the classic treatments of insulin resistance and Diabetes-related conditions. Previous data demonstrate that Pediococcus acidilactici CECT9879 (pA1c®) is effective in regulating blood glucose and has anti-diabetic activity.

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• High resolution analysis of multi-strain probiotic products by NGS using innovative molecular markers

  Within the TITAN project, Microbion developed an innovative metabarcoding method for the quality control of multi-strain products. Using Microbion’s HPME markers it’s possible to clearly distinguish all bacterial species and subspecies in the sample, and possibly also specific strains.

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• Optimizing dairy-free & animal-free culture media for industrial-scale production of Bifidobacterium

  In this study, we evaluated the potential of yeast peptones to produce Bifidobacteria in dairy-free culture media.

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